Sandy Hook students won't return to class until January






STORY HIGHLIGHTS


  • 6-year-olds Jessica Rekos and James Mattioli are laid to rest

  • School won't start for Sandy Hook children until January

  • The NRA says it is "prepared to offer meaningful contributions"

  • Investigators are so far unable to retrieve data from a computer taken from the gunman's home




Watch CNN's LIVE TV coverage of the Connecticut elementary school shooting as the story continues to unfold. People are sharing their concern and sadness about the Newtown school shooting. What are your thoughts? Share them with CNN iReport.


Newtown, Connecticut (CNN) -- Attendance was taken at schools across this devastated town on Tuesday as most students returned to the classroom for the first time since the deadly school shooting.


Not everyone was there.


Sandy Hook Elementary students won't resume classes until January, and victims of last week's massacre will never return.


Jessica Rekos and James Mattioli, both 6, were laid to rest Tuesday, while the families of Charlotte Bacon, 6, Daniel Barden, 7, and Victoria "Vicki" Soto, 27, held calling hours, or visitations, for their lost loved ones.


The teacher and children were among the 27 people killed when gunman Adam Lanza shot his mother and then went to the Sandy Hook, indiscriminately opening fire on staff and young students. The rampage reignited a debate about guns in America and sent shock waves through a nation that has seen mass killings before -- but not like this.









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"She had an answer for everything, she didn't miss a trick, and she outsmarted us every time. We called her our little CEO for the way she carefully thought out and planned everything," the family of Jessica said about their little girl, who loved horses and asked Santa for a cowgirl hat this year.


"We can not imagine our life without her," they said.


James liked to remind everyone that he was 6 and three-quarters. "He would often sing at the top of his lungs, and once asked, 'How old do I have to be to sing on a stage?'" his family wrote in an obituary.


In an online posting about his funeral, the Mattioli family called James "our beloved prince."


Across town, hearses could be seen traveling along roads with police escorts. Onlookers cried as they drove past.


Remembering the victims


For Sandy Hook students, no school until January


Unlike students at other schools who returned Tuesday, Sandy Hook students are not expected to go back until January.




Their school is a crime scene. The current plan is for them to resume classes next year at the former Chalk Hill Middle School, eight miles away in neighboring Monroe, Newtown Superintendent of Schools Janet Robinson said in a letter to parents.


"We need to tend to our teachers' and students' needs to feel comfortable after this trauma in this new place," she wrote.


Teachers may call parents "to invite you to visit Chalk Hill with your child this week to walk around and see the classroom and get familiar with this new Sandy Hook home."


At other schools, students went back to class with their sense of normalcy shattered. They were met by police, counselors and teachers, who all face a tremendous burden.


How do they explain to children what happened? How do they help make them feel safe?


David Schonfeld, a crisis counselor who gave a presentation to Newtown teachers about how to talk to students, said they have to meet children where they are.


"I told them that as far as I was concerned, there was really only one lesson plan that they needed to teach before they broke for the (holidays), and that was to make sure that the children knew that they were safe and that they cared about them and they were going to care for them," he said.


The teachers' union said classes would discuss the tragedy in an age-appropriate manner.


The gunman's computer and grim new details


Investigators have so far been unable to retrieve data from a computer taken from the home of the gunman, Adam Lanza, a law enforcement official said Tuesday.


It appears Lanza smashed the computer, extensively damaging the hard drive, the official said, adding that the FBI is assisting Connecticut State Police in trying to retrieve data from the computer.


Lanza's mother was shot four times in the head while she slept in her bed, said Connecticut Chief Medical Examiner H. Wayne Carver, also Tuesday.


Adam Lanza killed himself with a shot to the front of his head from a handgun, the medical examiner said.


Toxicology tests are under way to determine whether Adam Lanza had taken medication.


Growing debate over gun laws


What happened in Newtown should never happen again, advocates on both sides of the gun-control debate agree. But they're at staunch odds about how to turn words into reality.


The National Rifle Association commented Tuesday for the first time since the shooting, saying it was shocked and heartbroken by what happened. The group is planning to hold a news conference on Friday.


"Out of respect for the families, and as a matter of common decency, we have given time for mourning, prayer and a full investigation of the facts before commenting," it said. "The NRA is prepared to offer meaningful contributions to help make sure this never happens again."


The grassroots group Newtown United sent a delegation to Washington to meet with the Brady Campaign to Prevent Gun Violence as well as families from July's movie theater massacre in Aurora, Colorado.


The new group, which formed out of Newtown on Sunday, aims to create meaningful dialogue -- both locally and beyond -- about what may have led to the tragedy.


Until school shooting, 1 homicide in almost a decade


The debate is playing out not just in Newtown and Washington, but across the United States.


Two national polls conducted shortly after the Newtown massacre suggest that more Americans want stricter gun control.


In a Washington Post/ABC News poll, 54% of adults favor stricter gun control laws in the country, while 43% oppose.


And a new CBS News poll indicates that 57% of Americans back stricter gun laws, the highest percentage in a decade; 30% think gun laws should be kept as they are.


However, less than half of the respondents in the CBS poll -- 42% -- think stricter gun laws would have helped prevent what happened at Sandy Hook Elementary.


Sen. Joe Manchin, a conservative Democrat from West Virginia and a "proud gun owner," said he's now committed to "dialogue that would bring a total change" after the massacre in Newtown.


"Who would have ever thought, in America or anywhere in the world, that children would be slaughtered?" he asked. "It's changed me."


John Licata told CNN's iReport there needs to be better vetting before people buy guns, and assault weapons should be banned -- something Sen. Dianne Feinstein, D-California, says she'll propose once the new Congress convenes in January.


But some say the shooting illustrates the need for more armed guards -- and possibly armed teachers -- in schools.


Gun lobby has laid groundwork against any new laws


Texas Gov. Rick Perry said that if school districts decide that arming teachers is the best way to keep schools safe, so be it.


If Texas residents are duly background-checked, trained and have a concealed handgun license, "you should be able to carry your handgun anywhere in the state," Perry said, according to CNN affiliate WFAA.


Out of respect for the Newtown victims and their families, Dick's Sporting Goods has removed all guns from its store closest to Newtown, the company said.


Dick's, one of the largest sporting goods retailers in the world, also has suspended the sale of some semiautomatic rifles nationwide, the company said. It was unclear how long Dick's will keep its suspension of "modern sporting rifles."


Shedding new light on the gunman


While Carver, the chief medical examiner, said he was told that Adam Lanza had Asperger's syndrome, officials are working to determine whether that diagnosis was correct, and whether he may have had other diagnosable problems.


A former director of security for Newtown Public Schools shed new light Monday night on the gunman.


Richard Novia said Adam Lanza had Asperger's syndrome, based on documents and conversations with Lanza's mother.


Novia said that as part of his job, which he left in 2008, he would be informed of students who might pose problems to themselves or others.


He also said he received "intake information," which he said "is common for any students troubled or impaired or with disabilities." The idea was to keep track of and help students who may need it.


However, Novia said he never thought Lanza was a threat and certainly never thought he was capable of such violence.


After shooting, cops take no-tolerance approach to copycat threats


Russ Hanoman, a friend of Lanza's mother, previously told CNN that Lanza had Asperger's and that he was "very withdrawn emotionally."


CNN has not been able to independently confirm whether Lanza was diagnosed with autism or Asperger's, a higher-functioning form of autism. Both are developmental disorders, not mental illnesses.


Many experts say neither Asperger's syndrome nor autism can be blamed for the rampage.


"There is absolutely no evidence or any reliable research that suggests a linkage between autism and planned violence," the Autism Society said in a statement. "To imply or suggest that some linkage exists is wrong and is harmful to more than 1.5 million law-abiding, nonviolent and wonderful individuals who live with autism each day."


Dr. Max Wiznitzer, a pediatric neurologist and autism expert at Rainbow Babies and Children's Hospital in Cleveland, also said the gunman's actions can't be linked to autism spectrum disorders.


"Aggression and violence in the ASD population is reactive, not preplanned and deliberate," he said.


Gun control: 'This one feels different'


CNN's Susan Candiotti reported from Newtown; Dana Ford reported from Atlanta. CNN's Holly Yan, Greg Botelho, Sandra Endo, Josh Levs, Miriam Falco, Wayne Drash, Carol Cratty, Paul Steinhauser and David Williams contributed to this report.






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UBS to pay $1.5B in fines for rate manipulation

GENEVA Swiss bank UBS has agreed to pay $1.53 billion in fines to resolve allegations that it helped manipulate the benchmark LIBOR interest rate.

UBS announced Wednesday that its board of directors has authorized settlements with U.S., Swiss and British financial regulatory agencies.

Switzerland's largest bank is one of several leading banks under investigation over the possible manipulation of the LIBOR rate, short for London interbank offered rate. The LIBOR rate is used to set the interest rates on trillions of dollars in contracts around the world, including mortgages and credit cards.

In a proposed agreement with the U.S. Department of Justice, UBS has agreed to enter a plea to one count of wire fraud relating to the manipulation of certain benchmark interest rates.

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Newtown Settles In for Prayerful, Somber Christmas













Residents of Sandy Hook, Conn., gather every year under an enormous tree in the middle of town to sing carols and light the tree. The tree is lit this year, too, but the scene beneath it is starkly different.


The tree looms over hundreds of teddy bears and toys, but they are for children who will never receive them. The ornaments are adorned with names and jarringly recent birth dates.


Wreaths with pine cones and white ribbons hang near the tree, one each for a life lost. A small statue of an angel child sleeps among a sea of candles.


A steady flow of well-wishers, young and old, tearfully comes to cry, pray, light candles, leave gifts and share hugs and stories.


CLICK HERE for complete coverage of the massacre at Sandy Hook.


The Christmas season is a normally joyful time for this tight-knit village, but in the wake of a shooting rampage, holiday decorations have given way this year to memorial signs. And instead of cars with Christmas trees on top, there are media vans with satellites.


Connie Koch has lived in Newtown for nine years. She lives directly behind Sandy Hook Elementary School, where Adam Lanza, 20, killed 20 children and six adults before turning the gun on himself. Earlier that Friday morning, he had also killed his mother at home.










President Obama on Newtown Shooting: 'We Must Change' Watch Video







Koch said the shocked town, which includes the Village of Sandy Hook, is experiencing a notably different Christmas this year.


"It's more somber, much more time spent in prayer for our victims' families and our friends that have lost loved ones," she said as she stood near the base of the tree.


CLICK HERE for a tribute to the shooting victims.


Her family has been touched by the tragedy is multiple ways.


"My daughter, she lost her child that she babysat for for six years," she said, holding back tears. "And for her friend who lost her mother. And for my dear friend who lost one of her friends in the school, one of the aides.


"It's hard. And there will be much prayer on Christmas morning for these people, for our community."


Koch said her community always rallies in the face of tragedy, but the term "hits close to home" resonates this time more than ever before. She says the only way to make it through is one day at a time.


"It's all you can do, one hour at a time," Koch said. "For me, I don't even want to wake up in the morning because I don't want to have to face it again. You feel like it's still just a dream and with the funerals starting, it's becoming more real. It's becoming more final."


Another Newtown parent, Adam Zuckerman, stood by the makeshift memorial with a roll of red heart stickers with the words, "In Our" above a drawing of the Sandy Hook Elementary School welcome sign. He was selling the stickers to collect money for a Sandy Hook victims' fund.


"It's a lot," he said of the events of the past few days. "We don't know how it's going to affect our community, but I feel very strongly that I needed to do something to keep it positive, to keep this community positive."


Zuckerman's 20-year-old stepdaughter came home from college for winter break the night before the shooting. As a high school student, she worked in one of the town's popular toy stores.


"She knew a lot of the kids," he said of his daughter. "Their parents brought them in over the years. We have other friends who have lost family here and good friends who are dear friends with the principal of the school. … It's pretty rough."






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Fungal frog killer hops into crayfish








































Crayfish are vulnerable to the same fungus that is killing frogs all over the world. The discovery helps explain how the disease spreads even after all the amphibians in an area have been wiped out. Worryingly, chemicals released by the fungus may alone be enough to kill.












Taegan McMahon of the University of South Florida, Tampa, and colleagues discovered infected crayfish in field surveys in Louisiana and Colorado. They found that up to 29 per cent of the animals carried the chytrid fungus Batrachochytrium dendrobatidis. Lab studies proved that crayfish can become infected and die, the first time this has been shown in non-amphibians.













Infected crayfish can pass the disease to tadpoles, and crayfish exposed to water from which the fungus had been filtered still died. McMahon says the distribution of crayfish around the world may explain why the fungus is so widespread.












She adds that it is "is certainly possible" that other invertebrates might carry the fungus. Her team are currently investigating this and are working on possible ways to stop the spread of the toxin.












"It's very compelling, their evidence for crayfish as a disease vector and for a toxic effect secreted in the water," says Trenton Garner at London's Institute of Zoology.












PNAS, DOI: 10.1073/pnas.1200592110


















































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Malaysia Airlines to buy 36 turboprop planes






KUALA LUMPUR: Malaysia Airlines on Tuesday said it will buy 36 new ATR turboprop aircraft for 3.0 billion ringgit ($916 million) as it looks to further expand its regional and domestic networks.

Of the 36 ATR-72-600 planes, the carrier said 20 will go to subsidiary Firefly, which is fast expanding its lucrative routes, while 16 are for MASwings which flies to Sarawak and Sabah on Borneo island.

The purchase comes after struggling flag carrier Malaysia Airlines in November said it had swung back to a profit, ending six straight quarterly losses after slashing unprofitable routes to cut costs.

Malaysia Airlines group CEO Ahmad Jauhari Yahya said Firefly is expected to rapidly expand within the next five years, thanks to growing demand in Asia.

"The additional aircraft will be utilised to continue growing Firefly's network and providing customers with more travel options," said Ahmad Jauhari, who signed the deal with Filippo Bagnato, chief executive of French-Italian firm ATR.

The aircraft are slated to be delivered from the end of the second quarter of 2013.

Launched in April 2007, Firefly provides connections to various points within Malaysia, Thailand, Singapore and Indonesia's Sumatra.

Firefly currently has 12 ATR-72-500 aircraft while MASwings operates 10 similar aircraft.

- AFP/al



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Obama moves on taxes in latest "cliff" counter-proposal

President Obama gave up Monday on his demand for higher taxes on households earning $250,000 and upped it to $400,000 while embracing smaller cost-of-living Social Security raises in a counter-proposal to House Speaker John Boehner meant to narrow differences and forge a pre-Christmas "fiscal cliff" deal.

Mr. Obama and Boehner met for nearly an hour in the Oval Office on Monday and sources familiar with the talks released specific details of the White House proposal.

Boehner aides said it brought the two sides closer but said a deal was not at hand.

"Any movement away from the unrealistic offers the President has made previously is a step in the right direction, but a proposal that includes $1.3 trillion in revenue for only $930 billion in spending cuts cannot be considered balanced," said Brendan Buck, a Boehner spokesman.

Other senior Republican aides told reporters on Capitol Hill they are not rejecting the latest White House offer, but they also said that there is not parity or balance in the White House plan and substantive issues remain unresolved. One senior aide said the issues that they are talking about are not technically difficult to resolve, but they were wary the differences might be fundamental issues that are difficult to resolve.


But the depth, specificity and fine-grain nature of discussions over policy, tax revenue and spending cuts belied the tough rhetoric from the two sides in the negotiation. Signs point to a deal before the New Year's fiscal cliff deadline -- and possibly an announcement as early as Wednesday.




Play Video


Boehner's "fiscal cliff" offer brings optimism to Capitol Hill






Play Video


Boehner's "fiscal cliff" concessions come with a price



Talks picked up genuine momentum on Friday when Boehner agreed to higher income tax rates on households earning $1 million and above. Previously, Boehner opposed all income tax increases. He also gave in on raising the debt ceiling, a vote some Republicans wanted to use as leverage against Obama in 2013. Both gestures, top White House aides said, broke the logjam.

Mr. Obama responded with big concessions of his own on Monday. He offered a $400,000 income threshold for a Clinton-era top tax bracket of 39.6 percent. Boehner had proposed that tax rate for millionaires and a total 10-year tax revenue figure of $1 trillion. Obama wants $1.2 trillion in new revenue. Both sides look for hundreds of billions in new revenue in 2013 through a tax reform process that eliminates some tax deduction and closes loopholes.


The president also wants a two-year ceasefire on raising the debt ceiling. Boehner offered one year.


In addition to disagreement on income levels for tax rates or some other way to get more revenue, the two sides have not set in stone an actual tax reform process. It sounds like they are talking about creating a new sequester-like mechanism in 2014 as incentive for both tax reform and entitlement reforms.


Speaking of entitlements, Boehner also asked the White House to increase the eligibility age for Medicare but Mr. Obama again refused. This difference could loom large as Republicans want structural cost-saving changes in Medicare in exchange for raising income tax rates.

Mr. Obama has given ground on cost-of-living adjustments to Social Security and other federal benefits, but is trying to shield Medicare. Democrats have warned Obama they might bolt if he folds on raising Medicare's eligibility age. They have been less emphatic about cost-of-living adjustments.

Other components of the president's counter-proposal include:


  • $1.2 trillion in new income tax revenue with a 39.6 percent (up from 35 percent) on income of $400,000 or more.
  • $1.2 trillion in spending cuts divided this way: $800 billion in cuts; $290 billion in interest savings due to lower deficits; $130 billion in cost-of-living adjustments - - with specific protections to preserve increases for economically disadvantaged beneficiaries. Because changing cost-of-living adjustments would also affect where people fell in various tax brackets, this move would raise $90 billion
  • The $800 billion in cuts would come from $400 billion in savings to health care entitlements like Medicare and Medicaid; $200 billion in better tax revenue collection, increased financial transaction fees and reduced federal employee benefits.
  • $200 billion in domestic discretionary -- annual spending on basic government functions - divided equally between defense and non-defense programs.
  • At least $50 billion devoted next year to infrastructure spending and more in latter years - figures still subject to negotiation.
  • A one-year extension of unemployment insurance benefits.

Both sides have already agreed to create long-term solutions for the annual ritual of adjusting the Alternative Minimum Tax, the reimbursement formulas for Medicare physicians and a grab-bag of pro-business tax breaks.

Obama also did not ask for an extension of the temporary 2 percent payroll tax - a priority for some Democrats.

Funding for Superstorm Sandy will be handled separately from the emerging fiscal cliff package. The Senate is considering the administration's $60.4 billion request and the White House expects swift, bipartisan approval.

CBS News Capitol Hill producer Jill Jackson contributed to this report.

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Conn. Kids Laid to Rest: 'Our Hearts Are With You'













Visibly shaken attendees exiting the funeral today for 6-year-old Noah Pozner, one of 20 children killed in the Connecticut school massacre last week, said they were touched by a story that summed up the first-grader best.


His mother, Veronique, would often tell him how much she loved him and he'd respond: "Not as much as I [love] you," said a New York man who attended the funeral but was not a member of the family.


Noah's family had been scheduled to greet the public before the funeral service began at 1 p.m. at the Abraham L. Green & Son Funeral Home in Fairfield, Conn. The burial was to follow at the B'nai Israel Cemetery in Monroe, Conn. Those present said they were in awe at the composure of Noah's mother.


Rabbi Edgar Gluck, who attended the service, said the first person to speak was Noah's mother, who told mourners that her son's ambition when he grew up was to be either a director of a plant that makes tacos -- because that was his favorite food -- or to be a doctor.


Outside the funeral home, a small memorial lay with a sign reading: "Our hearts are with you, Noah." A red rose was also left behind along with two teddy bears with white flowers and a blue toy car with a note saying "Noah, rest in peace."


CLICK HERE for complete coverage of the tragedy at Sandy Hook.






Don Emmert/AFP/Getty Images













President Obama on Newtown Shooting: 'We Must Change' Watch Video







The funeral home was adorned with white balloons as members of the surrounding communities came also to pay their respects, which included a rabbi from Bridgeport. More than a dozen police officers were at the front of the funeral home, and an ambulance was on standby at a gas station at the corner.


U.S. Sen. Richard Blumenthal, U.S. Rep. and Sen.-Elect Chris Murphy and Gov. Dannel P. Malloy, all of Connecticut, were in attendance, the Connecticut Post reported.


Noah was an inquisitive boy who liked to figure out how things worked mechanically, The Associated Press reported. His twin sister, Arielle, was one of the students who survived when her teacher hid her class in the bathroom during the attack.


CLICK HERE for a tribute to the shooting victims.


The twins celebrated their sixth birthday last month. Noah's uncle Alexis Haller told the AP that he was "smart as a whip," gentle but with a rambunctious streak. He called his twin sister his best friend.


"They were always playing together, they loved to do things together," Haller said.


The funeral for Jack Pinto, 6, was also held today, at the Honan Funeral Home in Newtown. He was to be buried at Newtown Village Cemetery.


Jack's family said he loved football, skiing, wrestling and reading, and he also loved his school. Friends from his wrestling team attended his funeral today in their uniforms. One mourner said the message during the service was: "You're secure now. The worst is over."


Family members say they are not dwelling on his death, but instead on the gift of his life that they will cherish.


The family released a statement, saying, Jack was an "inspiration to all those who knew him."


"He had a wide smile that would simply light up the room and while we are all uncertain as to how we will ever cope without him, we choose to remember and celebrate his life," the statement said. "Not dwelling on the loss but instead on the gift that we were given and will forever cherish in our hearts forever."


Jack and Noah were two of 20 children killed Friday morning at Sandy Hook Elementary School in Newtown, Conn., when 20-year-old Adam Lanza sprayed two first-grade classrooms with bullets that also killed six adults.






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How human biology can prevent drug deaths






















Thousands of people die from adverse effects of medicines that have been tested on animals. There is a better way, say geneticist Kathy Archibald and pharmacologist Robert Coleman






















ADVERSE drug reactions are a major cause of death, killing 197,000 people annually in the European Union and upwards of 100,000 in the US. Little coverage is given to such grim statistics by governments or pharmaceutical companies, so patients and their doctors are not primed to be as vigilant as they should be, and adverse drug reactions (ADRs) remain seriously under-recognised and under-reported.












The €5.88-million EU-ADR project, which published its final report in October, showed that it is possible to spot these reactions earlier by applying data-mining techniques to electronic health records. These techniques could, for example, have detected the cardiovascular risk signals of arthritis drug Vioxx three years before the drug was withdrawn in 2004 - saving many tens of thousands of lives. But invaluable as such systems are, it would be even better to detect risk signals before a drug reaches humans, thus saving even more lives.












Currently, 92 per cent of new drugs fail clinical trials, even though they have successfully passed animal tests. This is mostly because of toxicity, which can be serious and even fatal for the people taking part in the trials. For example, in 2006, six people enrolled in a UK trial of the drug TGN1412 were hospitalised after developing multiple organ failure. Many clinical trials are now conducted in India, where, according to India's Tribune newspaper, at least 1725 people died in drug trials between 2007 and 2011. Clearly, there is an urgent need for better methods to predict the safety of medicines for patients as well as volunteers in clinical trials.












At the patient safety charity, Safer Medicines, we believe this goal is most likely to be achieved through a greatly increased focus on human, rather than animal, biology in preclinical drugs tests. New tests based on human biology can predict many adverse reactions that animal tests fail to do, and could, for example, have detected the risk signals produced by Vioxx, which in animal studies appeared to be safe, and even beneficial to the heart.












These techniques include: human tissue created by reprogramming cells from people with the relevant disease (dubbed "patient in a dish"); "body on a chip" devices, where human tissue samples on a silicon chip are linked by a circulating blood substitute; many computer modelling approaches, such as virtual organs, virtual patients and virtual clinical trials; and microdosing studies, where tiny doses of drugs given to volunteers allow scientists to study their metabolism in humans, safely and with unsurpassed accuracy. Then there are the more humble but no less valuable studies in ethically donated "waste" tissue.












These innovations promise precious insights into the functioning of the integrated human system. Many are already commercially available, but they are not being embraced with the enthusiasm they merit.












Pharmaceutical companies would make much greater use of them if governments encouraged it, but inflexible requirements for animal tests is a major deterrent. Ever since the thalidomide birth-defects tragedy, animal testing has been enshrined in law worldwide, despite the irony that more animal testing would not have prevented the release of thalidomide, because the drug harms very few species.


















So how well have animal tests protected us? Many studies have calculated the ability of animal tests to predict adverse reactions to be at or below 50 per cent. In 2008, a study in Theriogenology (vol 69, p 2) concluded: "On average, the extrapolated results from studies using tens of millions of animals fail to accurately predict human responses." And a recent study in Regulatory Toxicology and Pharmacology (vol 64, p 345) shows that animal tests missed 81 per cent of the serious side effects of 43 drugs that went on to harm patients.












It is hard to understand why governments defend a system with such a poor record, or why they are dismissive of new technologies that promise increased patient safety while decreasing the time and cost of drug development, not to mention the savings to healthcare systems from fewer adverse drug reactions. Proposals to compare human-based tests with animal-based approaches have been strongly supported by members of the UK parliament. The Early Day Motions they signed were among the most-signed of all parliamentary motions between 2005 and 2006, 2008 and 2009, and 2010 and 2012.












Safer Medicines has put these concerns to the UK Department of Health and the prime minister - to be told that "human biology-based tests are not better able to predict adverse drug reactions in humans than animal tests".












It is a tragedy that so many suffer or die through the use of inadequately tested drugs when tests based on human biology are readily available. Yet governments continue to mandate animal tests, despite the lack of a formal demonstration of fitness for purpose, and a growing global realisation among scientists that animal toxicity tests are inadequate and must be replaced.












In its 2007 report, Toxicity Testing in the 21st Century: A Vision and a Strategy, the US National Research Council called for the replacement of animal tests: "The vision for toxicity testing in the 21st century articulated here represents a paradigm shift from the use of experimental animals... toward the use of more efficient in vitro tests and computational techniques." To its credit, the US government is at least working on initiatives to hasten this. The UK government, however, still denies there is a problem. How many must die before it listens?




















Kathy Archibald is director of the Safer Medicines Trust. She is a geneticist who worked in the pharmaceutical industry.





Robert Coleman is a pharmacologist with pharmaceutical industry experience. He is now a drug discovery consultant and adviser to the trust



































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Myanmar courts wary investors on port project






YANGON: Myanmar is seeking to drum up investment in a stalled multi-billion-dollar sea port project at the heart of the former junta-ruled country's efforts to revive its impoverished economy.

Thai Prime Minister Yingluck Shinawatra and a host of Thai business leaders flew to Dawei on Myanmar's southern Andaman coast for talks with President Thein Sein and other officials about the joint development.

In July the two countries signed a memorandum of understanding to create a special economic zone for Dawei, with Bangkok agreeing to provide assistance in areas including security, infrastructure and logistics.

The huge project -- led by Thai industrial giant Ital-Thai -- would bring foreign investment for Myanmar as it emerges from decades of military rule, and provide Thailand with a gateway to the Indian Ocean and Western markets.

But it has faced funding difficulties and resistance from local villagers.

"Thai investors are afraid and hesitating about Myanmar's political policies and the funding," Ital-Thai marketing manager Pravee Komolkanchana told AFP in Bangkok ahead of the visit.

"Thai banks are less likely to lend money if it is to invest in other countries, especially in Myanmar."

He said a number of Japanese investors were also due to join the trip, which the company hopes will put the project back on track.

Potential Myanmar investors are also wary, according to a businessman in Yangon who did not want to be named.

"We dare not invest there because of the costs," he said. "We would have to pay Thai salary rates."

"The project won't benefit Myanmar much but mainly Thailand," he added.

Work has yet to progress far beyond the construction of new homes for the thousands of villagers due to be resettled.

Next year the developers hope to begin work on infrastructure and factories in a planned industrial zone.

Opponents to the plan were emboldened by Thein Sein's decision last year to suspend construction of a $3.6 billion Chinese-backed hydropower project in the northern state of Kachin in a rare response to public outcry.

But local resistance to Dawei appears to have eased, although some villagers are still reluctant to move despite the offer of new homes.

"We understand that we cannot stop the whole project," said a local environmental activist who did not want to be named, adding that campaigners had instead vowed to oppose any coal-fired plant or chemical factory.

- AFP/ck



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